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Antibody Processing

APBIO-VJIRKE

Antibodies are the effector proteins of humoral immunity. Depending on the stage of an immune response, these proteins can change from a membrane-bound form to one that is secreted into the bloodstream.

Which of the following is the processing mechanism that allows for the switch from a tethered form of the protein to one that is secreted?

A

Antibodies acting as surface receptors undergo an autocatalytic process, cleaving the membrane-spanning portion.

B

Alternative splicing creates a variant that is able to be secreted.

C

Genetic rearrangement at the DNA level allows for the deletion of the membrane domain.

D

Both forms are simultaneously produced.