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Cancer and p53

APBIO-4XEDNL

p53 is a protein that functions as a transcription factor, acting as a promoter for genes that lead to cell death in cells with damaged DNA. Sometimes cells also produce a protein called Mdm2 that also bonds with p53, preventing its attachment to DNA.

Which of the following is the MOST likely effect this would have?

A

Binding of Mdm2 to p53 would be beneficial to the regulation of damaged DNA.

B

Competitive inhibition by the Mdm2 could reduce p53 activity, resulting in an abnormal, cancerous cell.

C

Increased p53 activity could result in inappropriate apoptosis.

D

Decreased concentrations of unbound p53 could reduce cancerous activity in the cell.