Several antibiotics exert their action by targeting the unique protein synthesis processes in bacteria. They exploit the differences between prokaryotic and eukaryotic translation mechanisms to selectively inhibit protein synthesis in bacteria without affecting the eukaryotic host.
Ribosomes are a specific target of some antibiotics since there is a significant difference in size and structure between eukaryotic and prokaryotic ribosomes; eukaryotic ribosomes consist of a 60S subunit and a 40S subunit, whereas prokaryotic ribosomes are composed of 30S and 40S subunits.
Tetracycline is a common antibiotic that works at the level of protein synthesis in bacteria.
Which of the following provides the BEST explanation for the effectiveness of Tetracycline as an antibiotic in eukaryotic cells?