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Role of Progenitor Cells in Hematopoietic Stem Cell Development

APBIO-VJQYRL

Hematopoietic stem cells originate in mammalian bone marrow and are necessary for the continual production of blood cells. Hematopoietic stem cells (HSCs) are pluripotent, meaning they can differentiate into a limited scope of cell types, specifically red and white blood cells and platelets, provided the appropriate induction factors.

Using your knowledge of cell development, interpret the image below of the maturation and diversification of blood cell types.

Which of the following descriptions BEST explains the role of progenitor cells in the transformation of hematopoietic committed stem cells to mature stem cells?

Created for Albert.o. Copyright 2016. All rights reserved.

A

A progenitor cell serves as a link between committed and mature stem cells, allowing the direct and uninhibited reversal of mature cells when more stem cells are required.

B

Progenitor cells offer indefinite routes to all specialized blood cells.

C

A progenitor cell is a progressively committed stem cell, and therefore, demonstrates differentiative limitation towards targeted maturity.

D

As a required intermediate in blood cell development, progenitor cells undergo numerous cell divisions and transitions between diverse cell types in order to achieve maturity.