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The Role of ATP in Maintaining Ionic Homeostasis


If ATP was unavailable to the cell, as would be the case when treated with an uncoupler of oxidative phosphorylation, the effects would be numerous. Among them, $Na^+/K^+$ ATPase function would be inhibited.

Which of the following would be a consequence of such an inhibitory action?


Inhibiting the $Na^+ / K^+$ pump would cause a cessation of all ion movement.


Sodium would leak into the cell, and potassium would leak out of the cell, down their electrochemical gradients.


The ion concentration in the cell would "drift" towards that of the intercellular fluid.


Water would flow out of the cell, leading to crenation.