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Biochemistry

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Adapting Immunoglobulins to a Mutated Virus

BIOCHM-SERRLR

Influenza is a single-stranded, segmented RNA virus that causes the flu. The virus is capable of undergoing two processes - antigenic shift and antigenic drift - that allow it to evade the immune response by altering its hemagglutinin (HA) sequence. HA is a viral surface protein that facilitates viral entry into a host cell and it is a key target of antibodies.

Which of the following is a mechanism by which B cells, which secrete antibodies, might be able to adapt to a mutated influenza virus?

A

Allelic exclusion.

B

Alternative splicing.

C

Somatic hypermutation.

D

Class-switch recombination.