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Biochemistry

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Allosteric vs. Orthogonal Targeting

BIOCHM-RVTUXM

Enzymes can be targeted for inhibition directly at their active sites (orthogonal targeting) or at secondary/allosteric sites.

Which of the following is NOT considered a benefit of allosteric targeting?

A

It is easier to develop allosteric inhibitors.

B

There are more allosteric sites compared to orthogonal ones for any given protein.

C

Allosteric sites tend to be unique to the specific enzyme in question.

D

Incorrect dosing for an orthogonal inhibitor can lead to severe health/toxicity issues.