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Biochemistry

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Amino Acid Degradation: Transamination and Deamination

BIOCHM-ATNRF1

The cellular degradation of proteins yields free amino acids which can be further degraded by transamination and deamination reactions. The products of these reactions may lead to the biosynthesis of new compounds, energy, and/or the elimination of potentially toxic products.

Which of the following statements is NOT true regarding the degradation of amino acids?

A

Deamination of an amino acid leads to the removal of the amino group, which can be converted to ammonia and then urea for excretion.

B

Transamination does not result in any net deamination.

C

The oxidative deamination of glutamate by glutamate dehydrogenase (GDH) yields ammonia and alpha-ketoglutarate.

D

The oxidative deamination of glutamate by glutamate dehydrogenase (GDH) is stimulated by high GTP concentrations.

E

The oxidative deamination of glutamate by glutamate dehydrogenase (GDH) is inhibited by high NADH concentrations.