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Binding of Inhibitors to Enzymes


There are two major categories for types of inhibitors: irreversible and reversible. The latter category has three types: competitive, uncompetitive and non competitive (mixed). These inhibitors differ based on where they bind to an enzyme and when they bind in relationship to the substrate binding.

The type of inhibitor that forms a covalent bond with an enzyme and thus permanently disables it is


inhibitors do not form covalent bonds with enzymes. Among the reversible inhibitors,

bind at the active site in place of substrates. The other two types of reversible inhibitors do not bind at the active site but do so elsewhere on the enzyme. They differ in when they bind to the enzyme:

inhibitors only bind after the substrate has bound while

inhibitors bind either to free enzyme or the enzyme substrate complex.