Free Version

Upgrade subject to access all content


Components of Cholesterol Synthesis


The synthesis of cholesterol is a long and complex series of reactions. These many reactions can be subdivided into four steps, each with a particular substrate and product.

The synthesis of cholesterol begins with


These simplest building blocks are then converted into

in the first step and include the rate-limiting enzyme HMG-CoA reductase.

The second step involves a decarboxylase and produces


The third step combines several molecules to make

, which is finally acted upon by a monooxygenase and several other enzymes to yield a sterol product (including cholesterol).