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Biochemistry

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Components of Cholesterol Synthesis

BIOCHM-SYGCVF

The synthesis of cholesterol is a long and complex series of reactions. These many reactions can be subdivided into four steps, each with a particular substrate and product.

The synthesis of cholesterol begins with

molecules.

These simplest building blocks are then converted into

in the first step and include the rate-limiting enzyme HMG-CoA reductase.

The second step involves a decarboxylase and produces

.

The third step combines several molecules to make

, which is finally acted upon by a monooxygenase and several other enzymes to yield a sterol product (including cholesterol).