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Biochemistry

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Enzymes and Equilibrium

BIOCHM-IYC3O0

Lactate dehydrogenase is an enzyme that catalyzes the formation of lactate and NAD from NADH and pyruvate, both of which are products of glycolysis. The reaction is listed.

Assume that this reaction has reached equilibrium in muscle and then the muscle experiences an increased need for energy and consequently produces an increase in the amount of pyruvate.

Under these conditions, what would happen to the amount of lactate compared to the equilibrium condition? The reaction catalyzed is

$$\text{Pyruvate} + NADH \longrightarrow \text{Lactate} + NAD^+$$

A

There would be no change in the amount of lactate.

B

There would be a decrease in the amount of lactate.

C

There would be an increase in the amount of lactate.

D

There is not enough information to determine this.