Fatty acids are activated for oxidation in the cytosol by the formation of their respective fatty acyl-CoA ester. The enzyme carnitine palmitoyltransferase 1A (CPT1A) is localized outside of the inner mitochondrial membrane and catalyzes the esterification of fatty acyl-CoA molecules to acyl-carnitine molecules.
Mutations in CPT1A result in inhibition of carnitine palmitoyltransferase 1A activity and consequently, inhibition of long chain fatty acid oxidation. However, oxidation of medium (8-10 Cs) and very long-chain (>22 Cs) fatty acid oxidation is unaffected.
Identify ALL of the following statements which correctly explain why only long chain fatty acid oxidation is affected by a mutation in CPT1A.
Select ALL that apply.