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Biochemistry

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Moderate

Feedback Inhibition of a Metabolic Pathway

BIOCHM-3RKASN

Enzymes are often grouped into metabolic pathways that tend to share some common properties. Each pathway has a function and usually only a limited number of enzymes in the pathway are regulated. A common type of regulation in pathways is feedback inhibition.

A hypothetical biosynthetic pathway is shown. The goal of this pathway is to make the product, E, and the letters represent various intermediates while the numbers designate the enzymes of the pathway.

If this biosynthetic pathway shows feedback inhibition, which choice best describes what that means?

$$A\xrightarrow [ 1 ]{ } B\xrightarrow [ 2 ]{ } C\xrightarrow [ 3 ]{ } D\xrightarrow [ 4 ]{ } E$$

A

It means that E acts as a negative effector for enzyme 4.

B

It means that A acts a negative effector for enzyme 4.

C

It means that E acts as a negative effector for enzyme 1.

D

It means that A acts as a negative effector for enzyme 1.