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Biochemistry

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Glycoprotein vs. Proteoglycan

BIOCHM-K7DGMV

What is the primary difference between a glycoprotein and a proteoglycan?

A

In glycoproteins, the protein component is synthesized first, then a nascent carbohydrate group is covalently attached to the protein. For proteoglycans, the carbohydrate was generated first, then a newly-made peptide attached.

B

Glycoproteins are found only in the membrane and proteoglycans are found only in the cytosol.

C

Glycoproteins have a higher protein content by mass, being typically 50%+ of the total mass. Proteoglycans have a much higher carbohydrate content, with carbohydrates comprising typically 95%+ of the total mass.

D

There is no difference; the two terms are simply different terms for the same type of biomolecule.