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Helical Penalty

BIOCHM-GE4RQN

The term helical penalty is an estimation of the difference in free energy ($\Delta G$, estimated in kcal/mol) per amino acid residue in an $\alpha$-helical configuration compared to Alanine (set at zero).

Considering the structural conformation of an $\alpha$-helix, which amino acids would register a high helical penalty?

Select ALL that apply.

Higher $\Delta G$ values are not favourable thus compromising the integrity or stability of the secondary structure.

A

Phenylalanine.

B

Glycine.

C

Proline.

D

Tryptophan.

E

Tyrosine.