Thiazolidinediones, also known as glitazones, are a class of drugs used to treat Type II diabetes. All thiazolidinediones have the same functional group, shown below, but vary in R-group composition. Elevated levels of free fatty acids (FFAs) seem to promote insulin resistance.
Thiazolidinediones enhance the production of (up-regulate) PEPCK (phosphoenolpyruvate carboxykinase) in adipose tissue in order to promote insulin sensitivity. PEPCK is the enzyme responsible for converting oxaloacetate into phosphoenolpyruvate.
Which of the following statements help explain why increased concentration of PEPCK leads to lower levels of FFAs?
Select ALL that apply.