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Biochemistry

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Metabolism: Vitamin B1 (Thiamine) Deficiency

BIOCHM-5KLNNP

In people suffering from beriberi, a deficiency in vitamin B1 (thiamine), high levels of pyruvate are detected in the blood, especially after eating a meal rich in carbohydrates. α-ketoglutarate is also found in the blood at higher than normal levels.

In addition, the activity of transketolase, an enzyme which facilitates the transfer of 2-C units in the pentose phosphate pathway, is greatly reduced and used as a diagnostic assay for beriberi.

Which of the following is most likely NOT observed in humans suffering from beriberi?

A

Lower than normal activity of the pyruvate dehydrogenase complex.

B

Higher than normal levels of lactate.

C

Higher than normal levels of oxaloacetate.

D

Lower than normal concentrations of NADPH.

E

Lower than normal concentrations of ATP.

F

Lower than normal activity of the α-ketoglutarate dehydrogenase complex.