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Phosphofructokinase-1 and its Effector

BIOCHM-REKKP3

Phosphophofructokinase-1 (PFK-1) is a key regulatory enzyme in the glycolysis pathway. The reaction that it catalyzes is shown. ATP is a substrate for this enzyme and it also acts as a negative effector.

Which choice shown contains a statement that BEST describes the effect of ATP acting as a negative effector for this enzyme?

$$\text{fructose-6-phosphate + ATP} \ \xrightarrow [ ]{ } \ \text{fructose 1,6 bisphosphate}$$

A

On the Michaelis-Menten plot of velocity vs [fructose-6-phosphate], it will shift the curve to the right and increase the ${ S }_{ 0.5 }$ value.

B

On the Michaelis-Menten plot of velocity vs [fructose-6-phosphate], it will shift the curve to the right and decrease the${ S }_{ 0.5 }$ value.

C

On the Michaelis-Menten plot of velocity vs [fructose-6-phosphate], it will shift the curve to the left and increase the ${ S }_{ 0.5 }$ value.

D

On the Michaelis-Menten plot of velocity vs [fructose-6-phosphate], it will shift the curve to the left and decrease the ${ S }_{ 0.5 }$ value.

E

On the Michaelis-Menten plot of velocity vs [fructose-6-phosphate], it will not shift the curve at all.