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Biochemistry

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Phospholipid Formation in Bacteria: Phosphotidylethanolamine

BIOCHM-7MFUKA

In E. coli, the formation of many phospholipids begins with an activated diacylglycerol that has CDP linked to C-3. This CDP-diacylglycerol is then subject to nucleophilic attack to add various head groups in a phosphodiester linkage.

In order for E. coli to make phosphotidylethanolamine, what is the FIRST reaction that must occur to the CDP-diacylglycerol substrate?

Zirgouflex. "Phosphotidylethanolamine." N.p., 19 May 2009. Web. 23 Mar. 2016.

A

CDP-diacylglycerol is attacked by glycerol-3-phosphate.

B

CDP-diacylglycerol is attacked by serine.

C

CDP-diacylglycerol is attacked by ethanolamine.

D

CDP-diacylglycerol is attacked by water.

E

CDP-diacylglycerol is attacked by glycerol.