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Biochemistry

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Serine Protease and Blood Pressure

BIOCHM-6DBTXA

Plasma kallikrein is a serine protease that has a number of substrates including the zymogen form of bradykinin. Once released from zymogen form, bradykinin plays a role in regulating blood pressure; more specifically, it causes blood vessels to dilate which causes a decrease in blood pressure.

Like all serine proteases, plasma kallikrein has a serine at its active site.

If the gene that encodes the plasma kallikrein was mutated and the serine at the active site was changed to a phenylalanine, the effect on blood pressure compared to the normal version of the kallikrein would be

A

no change in blood pressure.

B

an increase in blood pressure.

C

a decrease in blood pressure.

D

not enough information to determine.