Glycosphingolipids, along with glycosaminoglycans and similar glycoproteins, are fairly complex biomolecules synthesized in multiple steps. Multiple enzymes, often glycosyl transferases specific for each sugar and acceptor, are involved. The mature molecule is often modified, particularly with the addition of sulfate groups attached by specific sulfotransferases. When it comes to degradation, glycosphingolipids and glycosaminoglycans are endocytosed into lysosomes. Once there, lysosomal enzymes cleave specific bonds until the molecules are fully degraded.
What general pattern holds TRUE for degradation of glycosphingolipids?