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Cellular and Molecular Biology

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Antibody Diversity and B cell Activation: Affinity Maturation

CELLS-RRHB1X

After binding antigen and undergoing activation, B cells undergo a process known as affinity maturation.

Which of the following statements is NOT true of affinity maturation?

A

It occurs in germinal centers.

B

It requires somatic hypermutation.

C

It requires follicular dendritic cells.

D

It requires negative selection.