A hallmark of the human immune system is the production of a large repertoire of B cells, each expressing antibodies with unique antigen-binding domains. B cell development occurs in the bone marrow and requires Ig gene rearrangement. In fact, a B cell must express surface antibody proteins in order to be considered mature, and leave the bone marrow.
Antibody diversity is generated through a variety of mechanisms.
Which of the following does NOT contribute to antibody diversity during B cell development?