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Antibody Diversity: B Cell Development and Ig Gene Rearrangement


A hallmark of the human immune system is the production of a large repertoire of B cells, each expressing antibodies with unique antigen-binding domains. B cell development occurs in the bone marrow and requires Ig gene rearrangement. In fact, a B cell must express surface antibody proteins in order to be considered mature, and leave the bone marrow.

Antibody diversity is generated through a variety of mechanisms.

Which of the following does NOT contribute to antibody diversity during B cell development?


Junctional flexibility during Ig gene rearrangement.


Somatic hypermutation within the Ig gene variable region.


Combinatorial joining of Ig gene coding segments.


P nucleotide addition during Ig gene rearrangement.