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Cellular and Molecular Biology

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Antibody Diversity: Loss of B cells During Development

CELLS-GN$6FW

During B cell development in the bone marrow, it is estimated that less than 11% of early stage pre-B cells progress to maturity, and the rest are eliminated via apoptosis.

Which of the following is LEAST likely to explain the high rate of apoptosis in developing B cells?

A

A disruption of the reading frame of an Ig gene coding sequence as a result of gene rearrangement.

B

The antibody protein produced by the developing B cell does not recognize the MHC molecule presenting the antigen as 'self'.

C

A misfolded Ig heavy chain protein is unable to successfully bind to the surrogate light chain.

D

The antibody protein produced by the developing B cell has an antigen-binding domain that binds to a 'self' protein.