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Cellular and Molecular Biology

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Antigen Presentation via MHC I Molecules

CELLS-6DKCDL

MHC I molecules present intracellular antigen to CD8+ T cells.

Which of the following BEST describes how antigen is loaded onto the MHC I molecule?

A

The antigen is transported into the rough endoplasmic reticulum (RER), where chaperone proteins load antigen into the binding cleft of the folded MHC I molecule.

B

The antigen is transported into the Golgi apparatus, where chaperone proteins load antigen into the binding cleft of the folded MHC I molecule.

C

The antigen is contained within a phagosome that fuses with an endosomal compartment containing the folded MHC I molecule. After fusion, chaperone proteins help load the antigen into the binding cleft of the MHC I molecule.

D

The MHC I molecule is transported to the cytoplasm, where chaperone proteins load the antigen into its binding cleft.