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Cellular and Molecular Biology

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B-Cells and Antibodies: Regulation of Ig Gene Expression

CELLS-L1ANLV

Despite being present in all cells, the Immunoglobulin (Ig) genes, which encode antibodies, are only expressed in B-cell lineages.

The best explanation for this observation is

A

MicroRNAs that specifically target Ig mRNAs for destruction are produced in all cells except B cells.

B

Cyclin-dependent kinases prevent the initiation of Ig gene transcription in all cells except B cells.

C

The Ig gene promoter regions have conserved sequences that bind transcription factors unique to B cells.

D

The cytokine interferon (IFN) signals specifically and only to B cells to activate Ig gene expression.