Cellular and Molecular Biology

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Cancer Cells and Initiation of Metastasis II


During metastasis, a cancer cell must become be less adhesive to neighboring cells and more migratory, undergoing what is termed the epithelial-mesenchymal transition.

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Genes that encode for proteins associated with the cell junctional complexes, such as the cadherins, are considered to be

since their expression is

in certain types of metastatic cancers compared to normal cells.