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Cellular and Molecular Biology

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Characterization of Cancer Cells

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Cancer results from mutations that accrue in the genome of normal cells over time. These types of mutations include small mutations such as point mutations, small insertions and deletions.

Larger structural changes in chromosomes include large insertions, deletions, inversions, and translocations. During the transition from a benign to a malignant state, cancer cells become aneuploid.

The method traditionally used to determine aneuploidy in a cancer cell is

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