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Cellular and Molecular Biology

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Clathrin-mediated Endocytosis

CELLS-EQRJS5

Clathrin is a well-studied coat protein. It is particularly necessary for endocytosis of a variety of plasma membrane receptors in different cell types. Clathrin is well-known for its assembly into icosahedral cages that form around vesicles prior to and during intracellular transport.

How is clathrin recruited to assemble over specific receptors?

A

Clathrin binding to receptors happens constitutively with endocytosis occurring once receptors have clustered at specific endocytic zones.

B

Receptor activation results in recruitment of specific adaptor proteins that subsequently facilitate assembly of a clathrin-coated pit.

C

Receptors recruit clathrin through phosphorylation of the clathrin heavy chains after receptor activation.

D

Receptor activation induces changes in membrane composition, allowing clathrin recruitment and self-assembly.