Cellular and Molecular Biology

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Comparison of MHC I and II Molecules

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There are two types of proteins that present antigen to T cells: MHC I and MHC II molecules.

All of the following statements are true of both MHC I and MHC II molecules EXCEPT

A

they exhibit polymorphism in the region that binds to peptides.

B

they have a glycoprotein heavy chain associated with a small protein light chain.

C

they contain conserved immunoglobulin structural motifs and as such are classified as members of the immunoglobulin superfamily.

D

they exhibit peptide binding promiscuity, with each MHC molecule having the ability to bind multiple peptides.