In the Central Nervous System (CNS) neurons communicate with one other through the release of neurotransmitter from presynaptic neurons which bind to receptors located on postsynaptic neurons.
Although neurotransmission most often occurs from pre- to postsynaptic partners, retrograde neurotransmission also occurs via the release of endocannabinoids from the postsynaptic neuron.
Endocannabinoids are hydrophobic signaling molecules which bind to presynaptic receptors that subsequently cause a slow reduction in neurotransmitter release.
What is/are the mechanism(s) for this presynaptic form of inhibition?
Select ALL that apply.