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Cellular and Molecular Biology

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Epigenetics and Tumorigenesis

CELLS-LKTH0R

Changes in DNA methylation are recognized as major drivers of tumorigenesis.

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For example, 25% of acute myeloid leukemias arise from DNA hypomethylation in gene promoters. This is

in DNA methylation at

which leads to

in gene expression.

Conversely, a high proportion of colorectal cancers have DNA hypermethylation, which is

in DNA methylation that generally leads to

in gene expression.