Erythropoietin is a glycoprotein hormone that stimulates the production of red blood cells from progenitor cells in the bone marrow.
The organ that releases erythropoietin is the
. When oxygen levels drop, erythropoietin is released and travels to the bone marrow.
Erythropoietin receptors belong to the
family of receptors and are located on
precursor cells. The receptors preexist in a
state which demonstrates a conformational change upon stimulation by erythropoietin. The conformational changes result in
of preassociated JAK2 kinases.
and rescue of erythroid (red blood cell) progenitors from