Cellular and Molecular Biology

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Erythropoietin: Its Receptor and Its Function


Erythropoietin is a glycoprotein hormone that stimulates the production of red blood cells from progenitor cells in the bone marrow.

The organ that releases erythropoietin is the

. When oxygen levels drop, erythropoietin is released and travels to the bone marrow.
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Erythropoietin receptors belong to the

family of receptors and are located on

precursor cells. The receptors preexist in a

state which demonstrates a conformational change upon stimulation by erythropoietin. The conformational changes result in

of preassociated JAK2 kinases.
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Erythropoietin promotes

and rescue of erythroid (red blood cell) progenitors from