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Cellular and Molecular Biology

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Failure to Completely Sequence Genomes

CELLS-VPD4GF

Many genomes cannot be completely sequenced even with the latest next-generation sequencing methods.

Which of the following choices represents the best reason for this?

A

Portions of some genomes have unusually high mutation rates and change so rapidly that they cannot be easily sequenced.

B

Many organisms have DNA that cannot easily be extracted from their tissues.

C

Repetitive DNA sequences are highly unstable and usually deteriorate before they can be sequenced.

D

Highly repetitive DNA sequences cannot be resolved with current mapping and sequence assembly algorithms.