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Cellular and Molecular Biology

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Glial Control of Neural Process Shape

CELLS-ZOIX1D

The worm, C. elegans, has 12 special “amphid” sensory neurons, eleven of which are chemosensory and one is thermosensory. Amphids are invaginations in the head region of the worm.

Recent research as demonstrated that glial cells can influence the shape of the amphid sensory ending, thus controlling its function. Interestingly, the glial cell is able to localize a special ion channel in its membrane to the region of contact with only the thermosensory neuron and not the other neurons.

Chloride secreted from the glial cell stimulates the neural ending, thus changing its shape. Without the chloride control of neural shape, the worms cannot remember their preferred temperature.

What is the most likely intracellular neural fiber system that is involved in the chloride control of the shape of the neural ending?

Hint: what intracellular neural fiber types are important in the sub-membranous cytoskeleton?

A

Fibronectin.

B

Myosin.

C

Neurotubule.

D

Intermediate fiber.

E

Actin.