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Cellular and Molecular Biology

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Identification of Tumor Suppressor Genes

CELLS-2BEK1Z

Cancer cells arise from mutations in two classes of genes, tumor suppressor genes and oncogenes. Tumor suppressor genes are viewed as the “brakes” that prevent premature progression through the cell cycle.

Oncogenes, derived from mutations that develop in normal proto-oncogenes encoded in the genome, act as the “gas” to accelerate cell proliferation. Generally tumor suppressor genes are lost or inactivated in cancer cells while oncogenes are highly expressed.

Which of the following statements concerning tumor suppressor genes and oncogenes is NOT correct?

A

Tumor suppressor genes act recessively.

B

Oncogenes act dominantly.

C

Gene therapy would be an effective strategy to treat cancers with oncogenic mutations.

D

Gene therapy would be an effective strategy to treat cancers with tumor suppressor gene mutations.