Cancer cells arise from mutations in two classes of genes, tumor suppressor genes and oncogenes. Tumor suppressor genes are viewed as the “brakes” that prevent premature progression through the cell cycle.
Oncogenes, derived from mutations that develop in normal proto-oncogenes encoded in the genome, act as the “gas” to accelerate cell proliferation. Generally tumor suppressor genes are lost or inactivated in cancer cells while oncogenes are highly expressed.
Which of the following statements concerning tumor suppressor genes and oncogenes is NOT correct?