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Cellular and Molecular Biology

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Innate Immunity and Vesicular Transport of Pathogens

CELLS-0EHYH1

Mycobacterium tuberculosis is a bacterial pathogen that survives inside the phagocytic vesicles of lung macrophages and multiplies instead of being killed. Cells containing the pathogen were stained to identify the location of lysosomal enzymes, and the compartments containing bacteria never stained positive for these enzymes.

You can conclude that the bacterium synthesized a protein that

A

interferes with clathrin-coated pit formation.

B

interferes with endosome trafficking.

C

interferes with the action of degradative hydrolases.

D

prevents early endosomes from contacting the phagocytic vacuole.