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Cellular and Molecular Biology

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Multidrug Resistance

CELLS-HBWJXX

The Mdr1 or Abcb1 gene encodes for a transport ATPase that pumps lipophilic drugs out of the cell.

Which of the following genetic alterations associated with the Mdr1 gene would make cancer cells less resistant to lipophilic chemotherapeutic drugs? Select ALL that apply.

A

Amplification of the Mdr1 gene.

B

Hypermethylation of CpG islands in the Mdr1 promoter.

C

Hypomethylation of CpG islands in the Mdr1 promoter.

D

A mutation in the Mdr1 gene that causes inactivation of the catalytic ATPase domain.