Cellular and Molecular Biology

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Nitric Oxide: Smooth Muscle Cell Signalling


Complete the information below using your knowledge of signaling transduction and nitric oxide (NO) signaling in smooth muscle relaxation.

A stimulus that activates a nerve terminal; this releases the neurotransmitter

, which binds to a receptor that activates an enzyme that produces

from arginine.

This molecule moves by rapid diffusion across membranes into the smooth muscle cells and binds to guanylyl cyclase which produces cyclic GMP from


The cyclic GMP can then activate the smooth muscle cells to respond and relax.