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Cellular and Molecular Biology

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Role of Tumor Suppressors in Cancer

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Tumor suppressor genes normally function to inhibit cell survival or cell proliferation, whereas proto-oncogenes promote cell survival or cell proliferation.

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Mutant forms of tumor-suppressor genes act

, meaning that

before their protective function is lost; in contrast oncogenes act

. This means that a gene therapy-based treatment for certain types of cancers would work best for mutations within

.