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Cellular and Molecular Biology

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Signaling Pathways: Receptor Protein-Tyrosine Phosphorylation

CELLS-6YVOBD

Receptor protein-tyrosine kinases (RTKs) are transmembrane proteins that contain an extracellular ligand-binding domain outside a cell and an intracellular domain within the cytoplasm that can activate downstream signaling pathways by phosphorylation.

What is true about RTK phosphorylation?

Select ALL that apply.

A

RTKs are active as dimers.

B

'Phosphorylation​' denotes the act of an enzyme catalyzing the transfer of phosphate groups.

C

RTKs act on a specific signalling protein.

D

The phosphate group transferred by the kinases come from elemental phosphate within the cytosol.