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Cellular and Molecular Biology

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Stimulatory Signals Required for the Activation of T Helper Cells

CELLS-K1AMOS

T helper cells require several signals to initiate proliferation and differentiation in an immune response.

Which of the following signals is NOT required for the full activation of T helper cells?

A

Binding of the T cell receptor (TCR) to the appropriate antigen, as presented by an MHC II molecule.

B

Interaction of CD28 with B7, displayed on the surface of an antigen presenting cell (APC).

C

Interaction of CTLA-4 with B7, displayed on the surface of an APC.

D

Binding of the cytokine IL-2 to its receptor on the surface of the T helper cell.