Cellular and Molecular Biology

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Subnuclear Domains: Cajal Bodies


Subcompartments in cells separate biochemical processes into confined spaces. This is critical for the efficient production and processing of cellular macromolecules.

Cajal bodies are

that are involved in the biogenesis of ribonucleoproteins (RNPs) involved in


maintenance on chromosomes, rRNA processing and

gene transcription (critical for DNA packaging).

Cajal bodies are dynamic and plentiful in proliferating or highly


They are assembled on their scaffolding protein,


of this protein leads to the disassembly of Cajal bodies.