Cellular and Molecular Biology

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Sumoylation: A Multifunctional Post-Translational Modification


Many proteins are modified following translation.

Sumoylation is a post-translational modification process similar to

in regard to the type of enzymatic reactions.

However, rather than

, sumoylation involves addition of


Sumoylation is involved with many processes involving proteins such as the subcellular localization of proteins, protein partnering, and transactivation functions of transcription factors.

The majority of proteins that are sumoylated are

proteins. Sumoylated proteins are covalently attached to

residues in proteins.