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Which of the following BEST describes the process of clonal anergy in an immune response?
Clonal anergy occurs when the T cell receptor (TCR) on a T helper cell engages with the appropriate antigen presented by an MHC I molecule. This results in activation of the T helper cell.
Clonal anergy occurs when the TCR on a T helper cell engages with the incorrect antigen presented by an MHC II molecule.
Clonal anergy occurs when a superantigen cross-links the TCR of a T helper cell and an MHC II molecule, regardless of antigen specificity.
Clonal anergy occurs when a T helper cell receives one, but not both co-stimulatory signals from an antigen presenting cell (APC). This results in a state of unresponsiveness.