Cellular and Molecular Biology

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The Tumor Suppressor Gene RB


Cancer can be viewed as a genetic disorder, with tumor suppressor genes acting recessively and oncogenes acting dominantly. The retinoblastoma gene RB was the first tumor suppressor gene discovered, and mutations in this gene occur sporadically in the population. Retinal tumors develop after both copies of RB are altered or eliminated.

What would be the outcome if cells from a tumor lacking a functional RB gene had a wild-type copy of the gene reintroduced into those cells?


The cancer phenotype would persist and remain the same.


The cancer phenotype would be more aggressive.


The cancer phenotype would be suppressed.


The cells would undergo apoptosis.