You are a graduate student in the lab of Sir Bernard Katz. Eager to earn your Ph. D, you accept a project trying to observe the fusion of synaptic vesicles with the plasma membrane, a key event in the release of neurotransmitter.
The only way you can visualize the fusion of membranes is by using transmission electron microscopy (TEM) since this is the only method with the resolving power needed to see synaptic vesicles and plasma membrane.
After years of failed attempts to visualize this event, you find that the harsh fixatives and sample preparation necessary for TEM studies actually distort the plasma membrane, preventing any observation of membrane fusion.
How do you solve this problem?