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Genetics and Genomics

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Genetics of T Lymphocytes in the Immune Response

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T cells are somatic cells essential to the human immune response.

T cells undergo the process known as somatic recombination, meaning these cells can rearrange their genetic information during their development, unlike the majority of the cells in the body. T cells originate in the bone marrow, after which they travel to the thymus to mature.

During the maturation process, the DNA of the T cell undergoes

A

V(D)J recombination; this produces the unique protein sequence of the immunoglobulins used by the T cells to recognize antigen.

B

V(D)J recombination; this produces the unique protein sequence of the hemoglobin molecule used to recognize antigen.

C

V(D)J recombination; this produces the unique protein sequence of the T cell receptor used to recognize antigen.

D

V(D)J recombination; this produces the unique protein sequence of the hormone receptor used to recognize antigen.