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Genetics and Genomics

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Leading and Lagging Strand Explanation

GENES-YMZW0A

During replication of a DNA molecule, replication of the leading strand proceeds toward the replication fork, while the lagging strand is made in fragments in the opposite direction.

This difference in the synthesis of the two strands is the result of which of the following?

Select ALL that apply.

A

The two parental strands are antiparallel.

B

DNA polymerase is not efficient enough to make two 'good' strands of DNA.

C

The lagging strand is the result of DNA breakage due to UV light.

D

DNA polymerase synthesizes DNA only in the 5' to 3' direction.

E

The cell does not contain enough nucleotides to make two complete strands.