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Loss of Function Mutation in Ligase

GENES-XM1VLR

Consider the following scenario. A loss of function mutation in the ligase gene results in the absence of the ligase protein.

During DNA replication on the lagging strand of a eukaryotic chromosome, which of the following outcomes is MOST likely?

A

DNA cannot be unwound at the replication fork.

B

The addition of new nucleotide bases is halted.

C

Additional RNA primers cannot be synthesized.

D

Phosphodiester bonds between Okazaki fragments are not produced.

E

RNA primers cannot be excised and replaced with DNA.